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In the resting state, two proteins, troponin and tropomyosin, bind to actin molecules and inhibit interaction between actin and myosin, thereby blocking muscle contraction.
Agglomeration would be expected to reduce diffusivity and inhibit interaction of the Q-POSS molecules with microbial cells.
This study also suggested three types of potential peptide inhibitors against viral entry can be designed, those that simultaneously inhibit interaction with HRC and HRN and those that are either HRC-specific or HRN-specific.
Alternatively, cytoskeletal proteins can act as scaffolds to promote or inhibit interaction of signaling molecules.
107 Compounds were tested for their ability to inhibit interaction with a coactivator peptide of SRC-2.
These substitutions could inhibit interaction with the negatively charged phosphate groups linking the cap to the mRNA.
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Polypeptides designed to inhibit interactions between NMD factors specifically impede NMD when exogenously expressed in the cytoplasm.
Statins thus inhibit interactions between leukocytes and endothelial cells, preventing leukocyte transmigration from the vasculature, across the blood-retinal barrier [29, 32 34].
Mutations that inhibit interactions also significantly reduce Foxi1 dependent reporter gene activation.
The use of low affinity anti-viral drugs interfering with HIV-1 coreceptor interaction may allow targeting multiple cellular coreceptors while maintaining the ability to inhibit interactions of a viral glycoprotein, which is subject to frequent mutation.
However, PEG chains may inhibit interactions of ligand molecules immobilized on the carrier with the target.
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