Additional processes activated downstream of mTORC1 include ribosome biogenesis and protein synthesis, cellular events that, when inhibited, can extend lifespan (reviewed in [ 41]).
As this function requires its catalytic activity, it is also targetable using existing antitelomerase drugs which were designed to inhibit the telomere extending abilities of telomerase.
Food antiseptics are chemicals which could inhibit bacteria and extend the food's shelf life, and their content is usually small.
These results indicated that some AML cells rely on an efficient CHK1-mediated replication stress response for viability and that therapeutic strategies that inhibit CHK1 could extend current cytarabine-based treatments and overcome drug resistance.
Furthermore, antioxidants have also been shown to suppress cancer incidences, inhibit immunodeficiency and extend lifespan in A-T mice, in addition to neurological deficits [73], [78] [81].
Bmi-1 inhibit senescence and extended the life span of normal human cell by suppressing p16INK4A that allows cell entry into division[ 45].
Nervous-tissue expression of one of these dominant p53 transgenes (p53 point mutation 259H) was found to inhibit IIS and extend life span in females [ 17, 18].
Storage pre-treatments, such as biotic or abiotic typological treatments, can be used to inhibit disease and extend the shelf-life.
Furthermore, we could show that CX4-M1, as well as CX4-Mc, but not CR5-M, are selectively recognized by anti-CXCR4 antibodies, bind to SDF-1α, and also inhibit SDF-1α signaling, extending the scope of selective functional CXCR4 mimicry through CX4-M1.
These temperatures inhibit fruit ripening, thereby extending fruit postharvest life.
