Overexpression of this peptide in target tissues therefore competitively inhibits entry of the Plasmodium parasite.
Also, both chlorpromazine and Bafilomycin A1 inhibited entry of infectious EBOV.
Cell cycle analysis showed that MS4a4B regulated T cell proliferation by inhibiting entry of the cells into S-G2/M phase.
Nevertheless, the observation that dynasore inhibits entry of BTV-1 into BHK cells shows that the entry mechanism is dynamin dependent.
The exogenous expression of TEX14 inhibits entry of ALIX into the midbody resulting in the formation of several interconnected somatic cells because of failure to complete cytokinesis.
Remarkably, bafilomycin A1 inhibited entry of VACV in S2 cells by 99% and was still 95% below the control after exposure to pH 5 buffer (Fig. 3C), suggesting that entry occurred predominantly or exclusively through a low pH endosomal route.
In latently infected human B cell lines, we found that rapamycin inhibited entry of the virus into the lytic replication cycle, marked by a loss of expression of the lytic switch protein, replication and transcription activator (RTA).
Thus far, our experiments demonstrated that when we inhibited entry of naïve CD8 T cells via HEVs to LNs, we observed increases in the number of T cells in lung and liver (Figure 3 4).
This deletion results in a nonfunctional receptor that inhibits entry of HIV into white blood cells.
None of the samples inhibited entry of NiV F/G-pseudotyped virus or neutralized either HeV or NiV.
The authors proposed that these compounds may hold the receptor in different conformations, thereby inhibiting entry of maraviroc-resistant variants.
