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This might be due to the fact that DBF and its metabolites are toxic and can inhibit degradation.
The extent to which substrates must be unfolded before translocation is not known, but substantial tertiary structure, and in particular nonlocal interactions such as disulfide bonds, are sufficient to inhibit degradation.
The transcriptome data analysis revealed that low oxygen supply has three major effects on metabolism: enhance carbon metabolism (glucose metabolism, pyruvate metabolism and carbon overflow), inhibit degradation of nitrogen sources (glutamate family amino acids and xanthine) and purine synthesis.
Mutations that directly impair the development and/or function of alveolar macrophages [50], as well as mutations that inhibit degradation of surfactant within these cells, have been shown to result in alveolar proteinosis and pulmonary dysfunction in both mouse and human [51].
CsA did not inhibit degradation of BACE457 (Figs. 1A 1B, lane 3 vs lane 2 and Figs 2B 2C, lanes 1 3), but substantially delayed the clearance from the ER lumen of BACE457Δ (Figs. 1C 1D, lane 3 vs lane 2 and Figs 2D 2E, 3B 3C, lanes 1 3) as efficiently as the conventional ERAD inhibitors Tg, Kif and PS341 (Figs. 1C 1D, lanes 4 6).
The Epstein Barr protein EBNA1 has an extensive set of Gly-Ala repeats that inhibit degradation.
Similar(38)
For example, it has been reported that Twist can be degraded through the ubiquitin/proteasome degradation pathway, as treatment with a proteasome inhibitor inhibits degradation of Twist [10].
On the other hand, addition of Br− slightly inhibited degradation possibly due to bromide scavenging of electrogenerated active species.
The unmodified tubular halloysite inhibited degradation, so that lower degrees of crystallinity were obtained in the halloysite based nanocomposite.
Thus, HEC-23-induced lysosome damage inhibited degradation of autophagosomes.
Data in this study show that USP33 interacts and stabilizes Robo1 protein level in lung cancer cells by inhibiting degradation via the ubiquitin proteasome pathway.
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