Exact(11)
The drugs omeprazole (Losec™ or Prilosec™) and lansoprazole (Prevacid™) also inhibit acid secretion by the parietal cells and are used as treatments for peptic ulcer.
TA were also shown to inhibit acid sphyngomyelinase (ASM), an enzyme catalyzing the hydrolysis of sphingomyelin to ceramide.
For example, tamoxifen and carmofur, which are currently used in anticancer treatment, were recently found to inhibit acid ceramidase activity.
Furthermore, our finding that both GF109203X and Rottlerin inhibit acid secretion and bone resorption potently, support a role for PKC in the acidification process in human osteoclasts.
Once converted to their active form, PPIs bind to cysteine residues in the proton pump and inhibit acid secretion into the canalicular lumen [ 16].
H2RAs inhibit acid secretion by competitively blocking histamine type-2 receptors on the parietal cell, thus reducing basal and stimulated gastric acid secretion.
Similar(49)
And the over-the-counter drug cimetidine, which inhibits acid production in the stomach and is used to treat heartburn, matched a certain type of lung cancer.
We had previously reported that IL1B inhibits acid secreting hormone gastrin by activating NFkB [12].
Hence, NO inhibits acid secretion in isolated human gastric glands.
Of these general PKC inhibitors, GF109203X inhibited acid influx potently.
Rottlerin, GF109203X, Hypericin and Ro31-8220 inhibited acid influx in microsomes and bone resorption, while Sphingosine and Palmitoyl-DL-carnitine-Cl showed low levels of inhibition.
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