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A mutation (Callipyge) in this broader imprinted region in sheep strongly deregulates expression of multiple genes within the core of this locus, including the maternally expressed miRNA, and causes postnatal skeletal muscle hypertrophy in select muscles in a rostro-caudal gradient across the animal but only when the mutation is inherited in the context of the paternal heterozygote [ 39].
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This perspective is also inherited in the concept of reading literacy (Groeben and Hurrrelmann 2004).
Certain types of intestinal neural tumors develop as multiple or diffuse polypoid lesions in the context of inherited syndromes.
Difference in TS expression might be of significance to varying outcome of MSI tumors seen in the context of inherited repair deficiency [ 33].
Our own recent experience of such work in the UK in the context of inherited cardiac disease (the Heart to Heart report [ 3]) included population needs assessment, service review, formulation of service standards, service specifications and guidelines and advice for commissioners.
We would not restrict future studies to de novo variants, however, because most rare variants are inherited and may have enhanced impact in the context of a 22q11.2 deletion (Stark et al. 2008; Forstner et al. 2013; Schofield et al. 2011; Brzustowicz and Bassett 2012; Merico et al. 2014).
Linked-marker studies are only useful in the context of alleles inherited by several family members, which must be included in the report.
The study of extracellular miRNAs in the context of the inherited muscle-wasting disorder Duchenne muscular dystrophy (DMD) is of particular interest.
The clinical and molecular characteristics of an individual tumor are the result of multiple mutations acquired over time and continued evolution of the responses to environment, all of this in the context of the inherited germline variations that affect tumor development.
Just 12 years ago, the origin of arthropods was almost invariably presented in the context of their inheriting the segmentation of their body from a shared ancestor with segmented worms, the Annelida (i.e., earthworms, leeches, polychaete worms).
The equation-based models include a representation of the uncertainty inherited in the data.
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