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However, compared with CADASIL-like patients, CADASIL patients demonstrated higher percentage of positive family histories (migraine and acute cerebral events) with autosomal dominant inheritance (Table 1).
In this study, we found no statistically significant difference between pretest and post-test for the CINS questions on variation and inheritance (Table 3).
Segregation analysis suggested that the LSE2 phenotype was caused by a recessive mutation in a single gene, while the segregation ratio for the LSE3 phenotype implied non-Mendelian inheritance (Table 1).
For the two large pedigree of Chaoshan, the models with the smallest AIC values were: recessive, dominant, and dominant with a polygenic mode of inheritance (table 5).
However, in most lines the number of the double transgenic progeny was not different from what was expected from Mendelian inheritance (Table 2), indicating that the microcephaly did not cause embryonic lethality in most lines.
In the NCCCTS cohort, significant allelic associations were observed for 1 SNP at ABCA4 (rs952499) and 5 SNPs at COL2A1 (rs6823, rs2070739, rs2276454, rs1635544, rs3803183) under a dominant model of inheritance (Table 3).
Similar(38)
The true breeding and monogenic nature of the herbicide tolerant mutant identified in the present study was evident from the results of progeny testing (Fig. 2), inheritance studies (Table 3), and SSR and DUS characterization (Additional file 2: Figure S1 and Additional file 1: Tables S1A and B).
We found that the risk alleles of 24 SNPs in 23 genes were associated with MI in both studies using an additive inheritance model (Table 2) and a P value threshold of 0.05.
MCB and genotyping errors were introduced to the disease models with various modes of inheritance relationship (Table 2) respectively according to Methods.
After association analysis in EPICOLON phase 1, 21 SNPs were statistically significant with an unadjusted P-value <0.05 in any of the tested inheritance models (Table 1).
We simulated matched pairs of placebo and control animals (n = 115), sampling with replacement from the 128 = 2 × 8 × 8 possible diallel categories and simulating treatment effects from only three inheritance classes (Table 3).
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