We also tested differences of genotypes between groups by analysis of multiple inheritance models but they were not statistically significant (Table 3).
The significance of the differences of observed alleles, genotypes and haplotypes between groups as well as analysis of multiple inheritance models (codominant, dominant, recessive, overdominant, and log-additive) were also tested using SNPStats (http://bioinfo.iconcologia.net/snpstats/start.htm).htm
Different inheritance models (codominant, dominant, recessive, and additive) were tested.
We tested different genetic inheritance models and a dominant model was applied in the final analyses.
For each study, we investigated the association between the alpha-adducin Gly460Trp polymorphism and hypertension risk, assuming different inheritance models of the 460Trp allele (Table 1).
The method of Mantel-Haenszel was used to calculate the odds ratio for the pooled data in a fixed-effects model, and, if there was evidence for heterogeneity, the DerSimonian-Laird method was used for the pooled odds ratio in a random-effects model, under pairwise comparisons of the different genotypes and dominant, recessive, and additive inheritance models.
To assess the importance of the identified associated SNP alleles in their genotype forms for association in IBD, five inheritance models (co-dominant, dominant, recessive, over-dominant and additive) were applied for statistical analysis to assess which one resulted in a best fit.
Genetic analysis filter was used to construct different inheritance models.
For SPP1 and LTBP4 genotypes, patients were grouped based on inheritance models specified above.
Additionally, we did not consider the inheritance models unless the general test of association was significant.
RTG uses the familial structure a priori to call variants segregating in the family under various inheritance models (see Methods).
