While therapeutic antibodies carry great potential due to the inherent specificity of binding and the multitude of surface proteins, there are specific issues in the case of GBM (and other brain tumors).
In this study, we developed a collagen-specific probe using a new approach that takes advantage of the inherent specificity of Glycoprotein VI (GPVI), the main platelet receptor for collagens I and III.
The workshop recommends general use of the term polyspecificity because it emphasizes two fundamental aspects, the inherent specificity of receptor recognition and the ability to recognize multiple ligands.
A valuable alternative to the more common ATP-mimetic based chemotherapies is a substrate-mimetic approach, which has the potential advantage of inherent specificity of the substrate-binding pocket.
In this study, collagen-specific fluorescent probes were developed using a new approach that takes advantage of the inherent specificity of collagen binding protein domains present in bacterial adhesion proteins (CNA35) and integrins (GST-α1I).
Immunoassays have been widely used in pharmaceutical and clinical analysis because of their inherent specificity, applicability for a wide range of analytes, high-throughput, and low cost [10].
The inherent specificity of 18 F-fluoride uptake implies that other causes of increased uptake such as the surgical procedure itself or underlying bone pathology such as spondylolisthesis or secondary spondyloarthrosis should be distinguished.
To capitalize on this inherent specificity, we sought to develop a small yet robust panel that could detect at least one mutation in the vast majority of cancers," says Joshua Cohen, an MD-PhD student at the Johns Hopkins University School of Medicine and the paper's first author.
Every DNA-binding protein has some sort of inherent specificity towards a combination of nucleotides due to its amino acids sequence and spatial configuration [47].
