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Therefore, the extracted time spans should be chosen carefully to include the inherent recurrence intervals of the tremor activity and to exclude longer-period variations or nonperiodic activity.
In contrast, a time span much longer than the inherent recurrence interval of periodic tremor bursts may be affected by the longer-period or nonperiodic activity, resulting in a τ c larger than the actual recurrence interval (Figure 6c).
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Inherent to the treatment of recurrence as a valuable and biologically meaningful tool to understand evolution is the notion that cases of repeated genomic evolution are informative if they occur in excess of the level of coincidence expected simply from the action of stochastic processes in finite sequence space.
The characteristic time correlates positively with locally measured median tremor duration, implying an inherent correlation between the moment release rate and the recurrence interval of tremors.
Recurrence risk studies can be challenging in other dimensions, including inherent biases, generalizability of findings, inadequate study size, and inappropriate use of analytic models to study recurrence.
The recurrence of this motif is linked to the inherent advantages resulting from backbone cyclization, which include increased resistance against proteolytic degradation, improved cell permeability, and tighter and more specific interaction with the respective biomolecular target.
CSCs are thought to constitute a small subset of cells within a tumor that initiate both the primary disease and its recurrence because of their capacity for self-renewal and inherent chemoresistance [ 5].
Since increased NF κB activation also correlates with chemotherapy resistance in solid tumours [ 60], it could be argued that drug resistant cells reside within the tumour and exhibit inherent activation of multiple signalling pathways, which eventually lead to tumour recurrence.
The original protocol also indicated recurrence at 1 year as a secondary outcome, however this was abandoned due to the inherent difficulties of distinguishing a true recurrence from a residual scar contracture, the lack of agreed definition of recurrence [ 15] and the subjectivity in visually inspecting and palpating the hand.
Hepatopancreatobiliary resections carry the inherent risk of subsequent biliary strictures (which may be due either to benign fibrosis at the anastomosis or disease recurrence) resulting in obstructive jaundice.
These observations are further evidence of an inherent molecular pathophysiology in DC disease fibroblasts that may help to explain the progression of the disease and its tendency to recurrence.
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