However, it is important to note that Ets-1 also down-regulated genes encoding certain H2O2-detoxifying enzymes, suggesting that these cancer cells likely require and maintain a certain level of H2O2 to encourage the high growth rates inherent to tumour progression.
Hypoxia-inducible factor 1α (HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mechanisms inherent to tumor progression.
Steatosis is an extremely common disorder affecting nearly 30% of the US population, among which 25% develop NASH with an inherent risk for progression to cirrhosis and hepatocarcinoma.
Thus, intra-tumor heterogeneity is an emerging mechanism of therapy resistance, not acquired under therapy selection but inherent to tumor progression.
Steatosis is a common disorder affecting obese patients; moreover, 25% of these patients develop steatohepatitis with an inherent risk for progression to hepatocarcinoma.
The narrative is powered by Ged's vices and virtues, and this intertwining of character and plot gives A Wizard of Earthsea an inherent rightness, like a progression of unexpected yet satisfying chord changes.
Due to their repetitive DNA sequence, unique architecture, bound shelterin proteins, and high propensity to form alternate/secondary DNA structures, telomeres are like common fragile sites and pose an inherent challenge to the progression of DNA replication, repair, and recombination apparatus.
Potential disadvantages of NAC are the inherent risk of disease progression preoperatively and the risk of liver toxicity.
We must be prepared to continue to face the possibility of violence in our path, based on an inherent faith in the progression of the human being, of society, and with humble reflection on our own revolutionary experience.
Varied approaches to clinical follow-up of EH contribute to the inherent difficulties of assessing progression risk (Zaino, 2000).
The fibrillary astrocytomas tumours have the inherent tendency for malignant progression to higher grade, with GBM as the most malignant phenotypic endpoint.
