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The main limitation of this study is the inherent observer bias, especially as regards variables such as age, where physical appearance can result in misclassification by the observer.
36 The main limitation of this study derives from the inherent observer bias, especially regarding variables such as age, as people can look younger or older than they actually are.
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There is inherent intra-observer and inter-observer variability given its subjectivity.
Manual interpretation of immunohistochemistry (IHC) is a subjective, time-consuming and variable process, with an inherent intra-observer and inter-observer variability.
Inherent in observer rated open-label studies is the risk of performance bias.
This was measured semiquantitatively with inherent potential observer bias and possible measurement error.
PCR-based assays are easy, rapid, sensitive, specific and quantitative approaches without the inherent inter-observer variability of IHC and FISH/CISH techniques.
Our study suggests that caregivers used their own lay assessment of the maturity of the adolescents as a basis of disclosing HIV status to them, a factor that could be plagued with inherent intra-observer biases.
Additionally, there are usually a large number of observers in epidemiological studies and there is always some subjectivity of observer inherent to the classification.
The inherent irony led observers to believe that the tirade could have been an attention-raising stunt by Baldwin, the star of the US satire on the television industry, 30 Rock.
Evaluation of stereoscopic retinal images at a reading center provides a uniform methodology for describing retinal lesions and changes in morphology over time that reduces the variability inherent with clinician observers in a multicenter trial.
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