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In summary, the designs of effective cancer clinical immunotherapeutic studies await acceptance of decision makers in cancer community that the inherent immune (cancer) surveillance that was recently defined as the balance between dual properties of Yin (tumoricidal) and Yang (tumorigenic) arms of effective immunity [18, 22, 44, 45, 62 65].
For instance, spread of HCV between host populations with inherent immune differences could have been a major evolutionary determinant.
What is not known, however, is how drug dynamics and kinetics affect inherent immune and transmission processes.
Many research results indicate that RA may be an inherent immune response [ 18].
Autoimmune-resistant strains (C57BL/6, BALB/c) did not display any of the abnormalities, suggesting a strong influence of inherent immune status and the neurodevelopmental toxicity of THI.
Not the inherent immune privilege of the CNS but the acquired immunosuppressive effect in glioma progression was the main cause of the suppressed FLNC antibody response in high-grade gliomas.
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Co-infected patients, however, have some inherent characteristics (deficient immune status, high HCV-RNA concentrations, particular genotype distribution, low response to antiviral therapy) that make the interpretation of such assays slightly different.
Such deleterious effects are extremely challenging to predict due to the inherent complexity of immune function in vivo.
Reports of spontaneous regressions, prolonged disease stability, and late relapses after nephrectomy suggest an inherent role of immune mechanisms in the natural history of RCC [ 5– 8].
However, because of the "memory" inherent to adaptive immune responses, the measurement in EOO mice at 15 weeks is a secondary response reflecting the initial response to aerosol OVA at 10 weeks.
An alternative, not mutually exclusive explanation, may relate to the high costs to the host inherent within their immune defence, where a lack of mounting such a response would result in the observed increasing parasite establishment and declining host virulence over time amongst these R-lines [ 36].
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