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Fusion genes are attractive as both therapeutic targets and diagnostic tools due to their inherent expression in tumor tissue alone.
Stable overexpression of HMGA1 was achieved in MiaPaCa2 cells, which have low inherent expression levels of HMGA1.
(Again note that these are differences between our RNA pools rather than inherent expression differences between general leaf and bud tissues).
Furthermore, the likelihood of genes with higher expression variability and inherent expression noise to be targeted by miRNAs is significantly higher than that of genes with stable expression level.
Because of the inherent expression of EGFR in MDA-MB-468 (amplified; EGFR++) and SKBR3 (EGFR+) cells, we also wanted to analyse whether EGF could induce S100A9 per se.
However the extent to which NK cell contribution derived from mice studies can be extended to humans is notably limited by the inherent expression of independently evolved and structurally unrelated set of MHC class I-specific NK cell receptors belonging to the C-type lectin-like family as opposed to the immunoglobulin-like family in humans (Parham, 2005).
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These performances, however, were not such as to make any large claims, whether in terms of inherent musical expression or of wider implications.
In 1996, Belgian Ilya Prigogine, a Nobel laureate, argued in The End of Certainty: Time, Chaos, and the New Laws of Nature that uncertainty is an inherent cosmic expression, deeply embedded within the core of reality.
These observations highlight the need to use naïve animals when investigating inherent gene expression differences.
In particular, it is necessary to confront a mathematical problem inherent in expression ratios.
Here, the aim was to identify a combination of genes whose inherent basal expression can predict the oyster capacity to survive infections.
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