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Possibly, exposure to dieldrin may lead to development of a tumor with an increased inherent aggressiveness beyond what this study could take into account i.e. tumor size, degree of spread, and stage of disease.
Cells undergoing EMT are characterized by their elongated morphology, inherent aggressiveness, propensity to maintain in long term cell culture conditions that is reminiscent of stem cell characteristics, which is also associated with resistance to standard chemotherapies and targeted therapies [ 2].
In general, the latter studies are more applicable to tumour sensitivity to therapy, as recurrence in the adjuvant setting is determined not only by response to systemic treatment but also by the extent of micrometastatic disease and inherent aggressiveness of the tumour.
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Multiple retrospective studies [ 10- 12] have reported that prognosis is poor among these patients, which could result from the lack of therapeutic options or inherent tumor aggressiveness [ 9].
In these cases, though there could be inherent 'tumor aggressiveness', significant iatrogenic factors contributing to the aggressiveness include breaching of cortex and accidental spillage at the time of curettage resulting in implantation of tumor tissue in soft tissues [ 2, 9, 14].
The aggressiveness is understandable.
"I like that aggressiveness.
It might be aggressiveness.
That aggressiveness pays dividends.
Aggressiveness was minimized.
Offensively we lacked aggressiveness.
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