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The predominant expression of these pumps and, in particular, MRP-1 suggests that they may be important contributors to the inherent aggressive and resistant nature of malignant melanoma.
This in turn is subject to modification by the genetic background, as we demonstrate by comparing an inherent aggressive with a less aggressive mouse strain.
A predominance of bettERNprognosis luminal A and B tumors and the strong downstaging trend over time suggest that late stage at diagnosis in the South African setting may be driven to a greater extent by nonbiologic determinants of stage at diagnosis rather than by the predominance of an inherent aggressive rapidly growing tumor, but must be confirmed in other studies.
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"One of the risks inherent in aggressive easing is the possibility of dislodging inflation expectations," Mr. Sack said.
In the United States, the British experience is being held up, by Democrats and mainstream economists, as an object lesson in the risks inherent in aggressive short-term budget-cutting amid signs that the recovery could be losing traction again.
In an Oct. 2 report, S&P says the firm's generally positive operating performance is offset by the financial risks inherent in aggressive expansion in a capital-intensive industry, and the resulting free-cash-flow deficits and high debt leverage.
This impasse offers a stark illustration of the risks inherent in making an aggressive opening offer.
Also, inherent to the proposed aggressive surface activities is the potential risk of injury to crewmembers.
It consists of the recognition of two powerful forces in direct opposition, namely, inherent instinctual (sexual and aggressive) needs and the need to live in a social group.
Underpinning it is the belief that men are inherent risk-takers or aggressive traders, and women are more naturally prone to long-term thinking or empathic and prosocial behaviour.
Third, by focusing only on residents with FTs we may have selected for a population with an inherent preference towards more aggressive care, including transfers to the acute care hospital.
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CEO of Professional Science Editing for Scientists @ prosciediting.com