PEGlyated nanoparticles also have the ability to passively target tumor tissues in vivo by exploiting the inherent abnormalities of the leaky tumor vasculature [31].
Molecular targeted agents that specifically modulate inherent abnormalities in malignant cells have opened new treatment possibilities.
Thus, on the one hand, the rather low IFNγ secretion of patient derived CD8+ TCCs might be due to inherent abnormalities of CD8+ (suppressor) T cell function in SLE, as shown recently by Filaci and colleagues [ 36].
At present, it is unclear whether autonomous PPAR-γ down-regulation represents a cell-inherent abnormality in gene regulation, such as epigenetic modifications at the PPAR-γ promoter, or results from constitutive autocrine TGF-ß stimulation.
According to our findings, even these clinically asymptomatic individuals can possess the inherent electrophysiological abnormality in their cardiac cells.
These abnormalities have been shown to normalise after continuous positive airway pressure treatment, suggesting induced rather than inherent trait abnormalities.
More robustly rhythmic tissues (WT SCN, WT and Vipr2−/− pituitary gland) did not show significant increases in rhythm amplitude following forskolin treatment (Table 2), presumably as these tissues had not yet significantly damped at the time of treatment and/or did not suffer any inherent rhythm abnormalities associated with a lack of VPAC2 receptors.
It is uncertain whether inherent labor abnormalities result in latent phase presentation and subsequent physician intervention or whether early presentation and subsequent physician intervention are the causes of the labor abnormalities [ 7].
AC is characterized by dramatic gene expression changes in tumour cells and has a high chance of early metastasizing, due to the inherent molecular abnormalities of lung cancer cells and the presence of an extremely dense blood and lymph vessel network.
Finally, a precise position is estimated using features inherent to the abnormality.
New onset symptomology of previously asymptomatic hydrosalpinx can also be due to abnormal tubal peristalsis activity or inherent congenital tubal abnormalities [2].
