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It is, for example still widely believed that a flow rate independent fine particle fraction contributes to an inhalation performance independent therapy, that dry powder inhalers perform best at 4 kPa (or 60 L/min) and that a high resistance device cannot be operated correctly by patients with reduced lung function.
The composite granules showed inhalation performance superior to that of freeze-dried nanosphere powder.
The blend of this fine powder and coarse crystalline lactose enhanced salbutamol sulphate inhalation performance.
In vitro inhalation performance and in vivo pharmacological effects of the IK312532/P5K-RP in antigen-sensitized rats were also evaluated.
This experimental setup allowed a general view on how drug and carrier properties affect the Fine Particle Fraction FPFF) as indicator for inhalation performance and gave the first study to distinguish between mannitol carrier particle shape and surface roughness.
In the present study, a dry powder inhaler system of IK312548 was designed for inhalation therapy with minimal systemic side effects, the physicochemical properties of which were also evaluated with a focus on morphology, particle size distribution, inhalation performance, and peptide stability.
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This study investigated the effects of hyperoxic gas inhalation on performance and SaO2 during high-intensity intermittent exercise.
This study investigated the effects of hyperoxic gas inhalation on performance and SaO2 during high-intensity intermittent cycling exercise.
This study utilises particle-engineered mannitol as an alternative carrier to discover the effect of mannitol carrier particle properties like particle shape, surface roughness, flowability or particle size on aerodynamic performance during inhalation.
In the intervention group, cognitive aspects increased by 23.7% and skilled performance of inhalation techniques increased by 66.4%.
As both relate to breath-holding it may be that participants in the singing group had learned to make a more relaxed and thus less deep inhalation leading to worse performance on these specific tests.
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