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Review methods All randomised clinical trials of B serrata extract as a treatment for any human medical condition were included and studies of B serrata preparations combined with other ingredients were excluded.
Pregnancy or nursing were specified as exclusion criteria in 17%% of NIS, and patients with known hypersensitivity to one or more ingredients were excluded in 16 % of the NIS.
Subjects using cholesterol lowering medications, supplements containing lutein or beta-carotene, medications that could affect drug or dietary supplement metabolism and excretion of drugs or dietary supplements, other natural health products including vitamins and minerals, or having an allergy or sensitivity to study supplement ingredients were excluded.
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If the active ingredients were unknown, then observations were excluded for all metabolites.
Additionally, if the family reported pesticide use in or around the home during the study period, then observations for metabolites of the active ingredients in the formulation applied were excluded for the day of and day after pesticide application.
Subjects allergic to wheat, fish, or any other ingredients in GD or the placebo were excluded.
These and similar interventions were excluded because they involved a single component where the active ingredient was clear or because they did not involve patient care.
Subjects were excluded if they had known allergies to test product ingredients or an uncontrolled disease such as diabetes, hypertension, hyperthyroidism, or hypothyroidism.
Preparations containing active pharmaceutical ingredients of herbal origin (e.g., codeine) that are available by prescription only were excluded.
Studies of preparations containing B serrata in combination with other ingredients, 2 3 non-randomised trials, 4 5 and abstracts reporting incomplete data for evaluation were excluded.
Patients with known hypersensitivity to gabapentin or its ingredients, pregnant or nursing women, and patients receiving other analgesic drugs indicated for neuropathic pain were excluded from the evaluation.
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