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Doing without it risks losing customers, and replacing it with more expensive ingredients risks losing profits.
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The ingredients include risks that are erroneously thought to be vanishingly small, complex technology that isn't fully grasped by either top management or regulators, and tricky relationships among companies that are not sure how much they can count on their partners.
In order to address the need for more sophisticated analytical techniques, we report our efforts to develop enhanced identification methods to screen pharmaceutical ingredients at risk for adulteration or substitution using field-deployable spectroscopic screening.
If the PEC/PNEC ratios are at hand for all relevant ingredients, the risk quotient of the product RQProd can be simply estimated by the PEC/PNEC sum: R Q Prod = R Q PEC / PNEC = ∑ i = 1 n PEC PNEC i × IF (8).
The lesson to small businesses in all this, food safety experts say, is that they need to know their ingredients and the risks, and know what to ask of suppliers.
In some of the secondary outcomes, such as risk perception, the relation with individual ingredients, such as risk communication, seems one-dimensional.
The equations that you cite from Alexander [primary source here] are mathematically flawed even if the first does at least identify the key risk ingredients.
A better approach would be that taken for food products by the F.D.A.'s Center for Food Safety and Nutrition, which requires a pre-marketing safety review only for certain high-risk ingredients.
If no ecotoxicological information is at hand for such ingredients, the only risk assessment option is the direct biotesting of the biocidal product or the resulting environmental mixture, respectively.
However, other studies reported that hair dyes and their ingredients pose no risk of adverse reproductive effects and a series of oral reproductive toxicology or embryo-fetal toxicity studies on commercial hair dyes found no evidence for reproductive effects (Nohyneka et al., 2004).
It can be hard to keep on top of what food ingredients are at risk of being a GMO because they are constantly changing.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com