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We searched the pathways of 160 SZGenes in the Ingenuity System (http://www.ingenuity.com) and found 101 canonical pathways.
Biological functions and pathways were generated and analyzed using Ingenuity Pathway Analysis® v.7.0 (IPA, Ingenuity System, CA) from all data and relevant gene-sets.
We conducted pathway analysis using Ingenuity System and constructed the first schizophrenia molecular network (SMN) based on protein interaction networks, pathways and literature survey.
The Ingenuity System was also used to calculate the likelihood of whether a specific lipid-related function in the "Global Functional Analysis and Global Canonical Pathwaysys" is due to random chance or the given biological process in lipid metabolic pathway is statistically significant.
All genes validated by RT-PCR were applied into Ingenuity system for core analysis.
We further analysed these 4082 genes that lose EZH2 binding upon differentiation by Ingenuity System Analysis.
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VCF files generated this way were directly inputted into ingenuity variant analysis (Ingenuity Systems, Redwood City, CA).
The differentially expressed proteins were analysed by MetaCore™ (Gene GO) and Ingenuity Pathway Analysis program (Ingenuity Systems).
Pathway analysis was carried out using Ingenuity Pathway Analysis (Ingenuity Systems, www.ingenuity.com).com
This target list was imported into Ingenuity Pathway Analysis Version 6.0-1202 (Ingenuity Systems®).
Further analysis was conducted using IPA – Ingenuity pathway analysis (Ingenuity Systems).
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