There's a moment in the first episode where Sherlock basically tells Watson all about himself and his life in an insulting way through observation, and Watson doesn't take offense, but rather responds with how awesome it was to experience ingenious deductive reasoning.
Here, their reasoning is a bit too ingenious.
The English physician and philosopher David Hartley announced in his Observations on Man (1749) that a certain "ingenious Friend" had shown him a solution of the "inverse problem" of reasoning from the occurrence of an event p times and its failure q times to the "original Ratio" of causes.
In the first, he and Tversky did a series of ingenious experiments that revealed twenty or so "cognitive biases" -- unconscious errors of reasoning that distort our judgment of the world.
As in the CDPS case, an ingenious combination of phylogenetic and genomic context analyses (already a standard in the field) with fully innovative chemical reasoning allows Aravind et al. to build a very solid case for a number of predicted biosynthetic pathways.
The ingenious asparagus peeler.
