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Patients received two infusions of a single tumor-reactive antigen-specific CTL clone expanded to 1010/m2; the first infusion was given without fludarabine conditioning, and the second CTL infusion was given after a course of fludarabine (25 mg/m2/days5 days).
After obtaining informed written consent, patients were randomized to receive coded infusions of a single pre-CPB dose (40 mg/kg) of TA (n = 80), and 40 mg/kg TA before and after (twice) CPB (n = 80).
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We now show that relatively rapid infusion of a single L-arginine infusion was safe at doses of up to 12 g infused at a rate of 24 g/hour in adults with moderately severe malaria.
For example, Faas et al. [ 88] showed that infusion of a single dose of endotoxin to pregnant rats caused glomerular damage in the kidney, as well as hypertension and proteinuria.
They underwent a second endoscopy with biopsies 4 weeks after the first infliximab infusion in case of a single infusion and at 6 weeks if they received a loading dose of infliximab at weeks 0, 2 and 6.
34 In this study, single doses of degarelix (1.5, 6.0, 15 or 30 μg/kg) were administered via 45-minute intravenous infusions, or a single dose of 20 mg was given intramuscularly or subcutaneously.
SR4554 was administered intravenously either over 30 or 60 min (depending on body surface area, hence volume of infusion) as a single dose on day 1.
The use of a single infusion or repeated infusions also needs to be addressed, even though multiple infusions could lead to right heart overload (and pulmonary hypertension) [ 27].
A time frame of 320 min of labeled VFA infusion employing a single injection allows accurate quantification of VFA metabolism in the rumen.
The EGFP-positive cells found in the BM of once-monthly-infused female recipients at the end of the experiments (15 infusions total) were unlikely to represent only cells from the last infusion, as a single infusion of cells derived from BM of β-actin-EGFP donors into non-conditioned wild-type recipients resulted in 0.8 ± 0.2% chimerism 2-4 weeks later (n = 4; Figure 5D).
The Allogeneic Human Cells (hMSC) in patients with Idiopathic Pulmonary Fibrosis via Intravenous Delivery (AETHER) trial was the first study designed to evaluate the safety of a single infusion of bone marrow derived mesenchymal stem cells in patients with idiopathic pulmonary fibrosis.
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