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Four ruminally cannulated cows each received aqueous infusions (based on water consumption of 100 L) of 0, 2, 5, and 12.5 mg/L Fe2+ as ferrous lactate, resulting in doses of 0, 200, 500 or 1,250 mg of Fe/d, in a 4 × 4 Latin square design for a 14-d period.
The encouraging anticancer effects documented in patients with refractory malignancies suggests that short gemcitabine infusions based on well-established cellular pharmacologic principles may improve the therapeutic index of this agent.
Blood pressure will be monitored closely throughout the infusions based on standardized safety protocols [ 5] that we have extensive experience performing in our CRC.
The number of infusions was transformed in a dichotomous factor 'more than three infusions' based on the relative risk for 'more than three medications added' (relative risk (RR), 2.9; 95% confidence interval (CI), 1.6 to 5.4) described by Inouye and colleagues [ 4].
All studies were consistent in observing substantial random fluctuation in 5-FU dose across the span of a continuous dose-rate infusion, and this needs to be taken into account in study designs that dose-adjust 5-FU levels of continuous infusions based on a plasma concentration [ 3].
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Regarding other protocols, in a study of cardiac surgery patients with diabetes, 61% of patients achieved the glucose target range of 4.4 to 8.3 mmol/L while on continuous insulin infusion based on the Portland protocol (paper-based) with a 7.1% hypoglycemia rate (BG <2.2 mmol/L) [ 4].
A recent review of published insulin-based glycaemic control protocols in intensive care identified protocols that adjusted insulin infusion based on frequently measured changes in blood glucose concentration as providing the best control [ 50].
Similarly, the use of standardized herbal material, occurring more frequently, makes the task of correlating the standardized herbal material to the infusion based dose data in the monographs more difficult.
The method efficiently separated several isobaric and near isobaric lipid species, which otherwise are difficult to quantify in direct infusion based profiling.
While a typical way for diabetes therapy is discrete insulin infusion based on long-time interval measurement, in this paper, we design a closed-loop control system for continuous drug infusion to improve the traditional discrete methods and make diabetes therapy automatic in practice.
In phase 1, following informed consent, the bone marrow transplantation laboratory at the clinical site is notified that there is an eligible patient and of the approximate time of the infusion (based on the planned start of the baseline infusion period).
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