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Spectra acquired within 28 s to 120 s from the start of sample infusion (timing required to stabilize the analyte flow and electrospray, as was judged by total ion current (TIC) trace) were averaged and recalibrated using m/z of synthetic standards SM 35∶1 and PC –O 20∶0/-O 20∶0 as references.
In particular, the questionnaire included body weight and body surface area, creatinine clearance, theoretical and really administrated dose of MTX, duration of infusion, timing dose, and MTX serum levels at 0, 248 48, and 72 h.
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Modulation by folinic acid, protracted venous infusion, or timing with circadian rhythms seem to have only marginal effects on response rates and survival.
There was no interaction by timing of infusion, and nonunion rates were similar even when ZOL was given within 2 weeks of hip fracture repair.
Correct timing of infusion and dose are important to avoiding oversaturation of physiologic transport mechanisms [ 33].
No significant differences in image quality was observed in malignant lesions relating to different timing of infusion.
Recently published trials have examined the effect of the timing of infusion of cell therapy on outcome.
Unlike colloid, timing of infusion of crystalloid may be important because of its short stay in intravascular space.
Therefore the timing of infusion may be the main key to prevent hypotension because the volume expanding effect is maximal at the time of administration.
Data, collected directly from the medical files, included details on oxytocin administration (ie, quantities, timing and infusion rates) and other aspects of labour (eg, cervical dilation at admission, duration of labour).
At this time, there is no clear evidence that CPT-11 chronomodulation can help to significantly increase effectiveness or tolerability of this drug, when it is used alone or in combination with 5-FU and it is compared to the standard 1-h infusion regardless of peak timing (Garufi et al, 2002; Giachetti et al, 2001).
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