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Primary cells were harvested from the infusion site at time points up to 3 months after vector administration to confirm vector DNA persistence.
Within each period, cows were assigned randomly to infusion site sequence: abomasum (A -cranial reticulorumen (R) or the reverse, R-A -cranial
Although most infusion site complications were minor, including local inflammation, phlebitis, and pain at the infusion site, some serious infusion site reactions did occur.
Infusion site reactions to a serious extent are quite rare.
Infusion site reactions were observed in one patient.
More immunoreactivity was observed at the infusion site.
Injection and infusion site reactions occurred in 4.9 % of CZP → CZP patients and 1.8%% of placebo → CZP patients; there were no incidences of serious infusion site reactions.
The most commonly reported treatment-emergent AEs were headache, infusion site reaction, and infusion site swelling (Table 5).>> No deaths or serious AEs occurred during this study.
One patient developed a painless skin pigmentation at the s.c. infusion site.
The most common adverse events were nausea, infusion site injury, and headache.
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32 Infusion site-related pain may occur in up to 90% of patients.
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