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No differences in gross pathology with either the ramped or non-ramped infusion procedure were observed.
United States antidoping officials now believe that Salazar and a Texas endocrinologist administered an infusion procedure in violation of antidoping rules, colluded to cover it up and then lied to their athletes about its legality.
AADC immunohistochemistry demonstrated that vector was distributed throughout the putamen, with no significant difference in volume of immunostaining with either infusion procedure.
In this study, a modified infusion procedure and a novel infusion device designed for use in humans (Clinical Device B) were evaluated for delivery of recombinant adeno-associated virus (AAV2) to brain.
Safety events occurred related to the infusion procedure and immunosuppression, including bleeding and decreased renal function.
Monitoring of the treatment was done according to the ketamine infusion procedure policy of the Department of Pain Medicine and Palliative Care at Mount Sinai Beth Israel (see Additional file 1 for sources used in protocol development).
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Details of our shRNA and control vectors, as well as our infusion procedures, are provided in Cozzoli et al (2012).
The primary endpoints were safety evaluation of the infusion procedures and assessment of transgene expression at 5.5 weeks post-infusion.
Infusion procedures were initiated simultaneously in two sites of the brain while MRI was continuously acquired.
Similarly, an August 2012 survey of 10 prominent specialty eye surgery facilities throughout the USA revealed that none had a policy defining infusion procedures for surgical teams performing OAFE during vitrectomy.
The entrances were the leaky microvessels that were either intrinsically hyperpermeable, with pores in the microvessel wall being larger than adenoviruses (Hobbs et al, 1998; Yuan, 1998) or damaged by the infusion procedures.
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