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ClinicalTrials.gov number; NCT00209768 Infusion of particles is a side effect of intravenous therapy [ 1- 3].
The majority of adverse events with radioembolization are caused by inadvertent infusion of particles into nondetected extrahepatic vessels.
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The infusion of particle-containing solutions could partially generate or at least aggravate ARDS and respiratory insufficiency.
Intravenous infusion of MnO@SiO2 particles showed little enhancement in any tissue except gallbladder.
This result clearly suggests that intravenous injection of pI before infusion of AAV2 particles results in a reduced uptake of the virus by APCs, which in turn leads to a reduced production of NAF.
The results obtained with cationic polymers, and in particular polylysines, showed that co- or pre-injection a few minutes before infusion of AAV2 particles significantly increases the overall transduction efficiency.
Before and 24 36 h after intravenous infusion of USIOP (particle size 30 nm; Sinerem, Guerbet, Paris, France) at a dose of 2.6 mg Fe/kg MR images were acquired using high resolution 3D T1-weighted and 2D T2*-weighted sequences.
The therapy involved an infusion of trillions of particles of the OTC gene, encased in a weakened cold virus, adenovirus.
It involved an infusion of trillions of particles of the ornithine transcarbamylase gene, tucked inside a weakened cold virus.
Inline filtration prevents the infusion of potentially harmful particles.
Our observation that ApoA1 variability, at least within the physiologic range, in humans is unlikely to affect insulin sensitivity is consistent with a recent elegant experiment in type 2 diabetic patients, in whom a 4-h infusion of reconstituted HDL particles doubled serum ApoA1 concentrations and increased HDL cholesterol by 20% but had no effect on insulin sensitivity (26).
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