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The device was prematurely disconnected (that is, before 24 hours in the first 65 patients, or before 72 hours in the remaining 10 patients) in 8 patients because of early patient discharge, death, or the necessity to use the lumen of the CVC for infusion of medication, and in 26 patients because of device errors (two patients) or problems with withdrawal of blood from the central venous line.
This outcome was not relevant, as both trials involved the infusion of medication, not fluids for hydration.
Continuous infusion of medication and solutions theoretically leads to less release of mast cell mediators and is preferred over single boluses.
Intrathecal drug delivery (ITDD or IDD) is a method which provides analgesia by a direct continuous infusion of medication into the cerebrospinal fluid (CSF).
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Central venous access could not be achieved, and peripheral venous access allowed for the infusion of medications and resuscitation fluids but not for withdrawal of blood for laboratory testing due to marked venous collapse.
Articles reporting infusion of medications or contrast media were excluded, as were articles that focussed on sensitivity to hyaluronidase.
Two cross-over trials compared the intraperitoneal and subcutaneous routes for infusion of medications (Liebl 2009; Selam 1983).
Spinal infusion of medications has been used for years, but there is little evidence of its efficacy in neuropathic pain and none in Chiari syndrome.
In addition, critically ill patients may receive numerous infusions of medications which can have disturbing side effects such as hallucinations and delirium.
Exclusion criteria were moribund status, pregnancy or breastfeeding, infusion of another medication via the central venous port used for norepinephrine administration, absence of healthcare insurance, refusal of the patient or next of kin to participate in the study, pheochromocytoma, and carcinoid tumor.
Nausea and vomiting were associated with infusion of the medication.
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CEO of Professional Science Editing for Scientists @ prosciediting.com