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Animal studies in rats have demonstrated that a parenteral infusion of dose 15 mg/kg has the potential to lower the mean, systolic, and diastolic blood pressures for more than half an hour.
The first, non-sequestered, component was just a constant infusion of Dose × (1-frdose).
Medication during maintenance was as follows: fentanyl in continuous intravenous infusion of dose 1 to 2 μg/kg, midazolam (0.1 to 0.2 mg/kg), and interrupted doses of rocuronium.
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However, the infusion T. violacea, 20 min after pre-treatment of the rats with atropine (5.12 mg/kg), led to dose-dependent increases in the BP and HR of the rats, as opposed to the hypotensive effect previously seen with the infusion of doses of T. violacea alone.
Repeated intraperitoneal administration of phIL-12/PPC for 4 weeks (weekly infusions of doses: 0.6, 3, 12, or 24 mg/m) was well tolerated and induced mild-to-moderate side effects, most frequently abdominal pain and discomfort.
But recent studies have shown that continuous infusion of high dose of oximes shows better outcome when compared to intermittent dosing.
We have previously validated a method of measuring GFR using a continuous infusion of low dose Iohexol (CILDI) in patients with stable renal function and calculate that variations >10.3% depicts AKI (p = 0.003).
This study evaluated the feasibility, toxicity, response rate and survival of neoadjuvant superselective intra-arterial infusion of high dose carboplatin in advanced head and neck cancer.
Tagliaferri and coworkers [ 37] found side effects on heart electric conductance following infusion of high dose verapamil incorporated into cytotoxic chemotherapy.
Recent evidence has shown that a continuous infusion of low dose furosemide - starting before cardiopulmonary bypass (CPB) - has detrimental effects on renal function [ 1].
The infusion of low-dose dopamine (defined as a dose lower than 5 μg/kg per min administered to normotensive patients) may not improve gut mucosal perfusion.
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