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Rats (n=11) were implanted with bilateral infusion guide cannula consisting of a 5 mm plastic pedestal holding two 26 gauge metal tubes 1.2 mm apart and projecting 4.5 mm from the pedestal was implanted through small holes drilled in the skull.
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Also, the experience is that fluid infusion guided by focus on blood pressure allows for wide variation in the administered volume.
Subjects were randomly assigned to intensive treatment (three or more insulin injections daily or continuous subcutaneous insulin infusion, guided by frequent self-monitoring of blood glucose) or conventional treatment (one or two insulin injections daily) and followed for 4 9 years (mean 6.5 years) (1, 9).
Consideration should be given to reduced dosing intervals or the use of continuous infusions guided by appropriate monitoring, to ensure therapeutic plasma levels.
Total intravenous anesthesia with propofol using target-controlled infusion technique guided by Bispectral Index monitoring ensures an optimum level of anesthesia.
According to current guidelines [5], fluid replacement and vasopressor infusion, both guided by hemodynamic monitoring, must be titrated in order to increase mean arterial pressure to 65 mmHg and possibly to higher levels for patients with chronic hypertension [6, 7].
An individual adjustment of AVP infusion rate guided by a MAP of 90 mmHg did not principally alter any of the parameters.
Epinephrine infusion was guided by the status of the supported ventricle; if possible, doses of less than 0.1 μg·kg-1·min-1 were used.
Insulin infusion rates were guided according to the same algorithm in both groups.
In the control group insulin infusion rates were guided by selective arterial blood glucose measurements, obtained using an automated blood gas analyzer (Radiometer ABL 700®, Copenhagen, Denmark).
These preliminary results suggest that the combination of continuous bedside EEG and therapeutic drug monitoring may be useful for titrating midazolam infusions and to guide tapering to avoid prolonged coma in patients with variable clearance of midazolam.
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