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A better method is to calculate the context-sensitive decrement times (context-sensitive referring to the infusion duration).
Preclinical data suggested that gemcitabine efficacy could be improved by increasing the dose or by increasing the infusion duration.
Indeed, varying infusion duration between 5 and 100 s produces differences in the rate of rise of cocaine concentrations in the brain, without producing large effects on peak concentrations [8, 9, 14].
Moreover, our approach permits to elucidate the effects on the final temperature profile of the following control parameters: infusion duration and flow rate, nanoparticles concentration in the nanofluid, magnetic field intensity and frequency.
These are not represented by a single number: they are a continuum of time values that are a function of infusion duration and can be represented by a graph.
Arrow indicates infusion duration.
Strategies include escalating dose and increasing infusion duration.
Figure 8 Loss of information by prolonging the infusion duration.
Extending the infusion duration to 4 h should allow the attainment of several times the MIC.
SYNOPSIS A careful stepwise method of enzyme replacement therapy (ERT) rate escalation can safely reduce infusion duration in patients with Pompe disease.
Reported here in detail are five patients with IOPD on 40mg/kg/weekly ERT in whom infusion duration was decreased with individualized, stepwise rate escalation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com