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Carriers of germline DICER1 mutations are predisposed to a rare cancer syndrome, the DICER1 syndrome, with a higher risk of numerous tumors and infrequently differentiated thyroid carcinomas.
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The expansion of GSCs in our defined cell culture medium also infrequently generated differentiated progeny, which represented a small fraction of cells.
Alternatively, stem cells can divide infrequently, and the differentiated cells are long lived (slow turnover).
Conversely stem cells that turnover slowly and thus divide infrequently generate long lived differentiated cells; a trait arguably favourable within adult tissues [ 8, 77].
Long-term maintenance of progenitor identity suggests that SOX2- and SOX9-expressing cells are tissue stem cells, although these give rise to differentiated progeny infrequently in unchallenged adult animals.
The Infrequently Active and Frequently Active groups were differentiated using the 5 day cut-point because this cut-point resulted in the most comparably sized groups.
Stem cell compartments are organised in a hierarchical manner with a small number of infrequently proliferating pluripotent stem cells, of rapidly dividing developmentally committed transit amplifying cells and of post-mitotic terminally differentiated cells [ 1].
Nuclear label retention for extended periods in individual cells may be due to the presence of labeled cells that differentiated and exited the cell-cycle shortly after the label was administered or may represent quiescent cells that divide infrequently or traverse the cell cycle very slowly.
It's differentiated.
A property of tissue stem cells is that they divide infrequently, and when they divide, one daughter is a stem cell and the other daughter differentiates and replicates several times, giving rise to differentiated progeny.
Boogaard fought infrequently.
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