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Chronic constipation is diagnosed using the Rome III criteria (3) or, more commonly in clinical practice, by the patient's symptoms of infrequent, difficult, or unsatisfactory bowel evacuation.
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Although pancreatic substitutes are generally successful at correcting hyperglycemia in small diabetic animal models, success with large animals, especially non-human primates, is infrequent and difficult to reproduce.
In general, constipation is defined as infrequent or difficult passage of stool.
Constipation, defined as infrequent or difficult evacuation of feces [ 1], is a worldwide functional gastrointestinal disorder.
Studies involving air pollution effects on animal models of human cardiopulmonary diseases are both infrequent and difficult to interpret.
13 The American College of Gastroenterology states that "constipation is characterized by unsatisfactory defecation that results from infrequent stools, difficult stool passage, or both".
Chronic constipation may be defined as 'a symptom-based disorder defined as unsatisfactory defecation characterised by infrequent stools, difficult stool passage, or both, for at least three months' [ 1].
Anti-cN-1A autoantibodies were detected by ELISA with moderate sensitivity, but high specificity for sIBM and may therefore help diagnose this infrequent and difficult-to-diagnose myopathy.
Because cases of pancreatitis are infrequent, it is difficult to accurately estimate the relative risk.
Complications after THA are infrequent but often difficult to manage [ 15].
Validating patient reporting in an outpatient population with infrequent seizures is difficult and to date has not been done.
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