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Some genetic studies have reported infrequent associations of specific genes with TS, including the mutation of SLITRK1 encoding SLIT and NTRK-like protein 1 and a rare functional mutation in the HDC gene encoding L-histidine decarboxylase [ 2- 9].
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This suggests an infrequent association of AC to aspiration pneumonia [113].
In the present investigation, subgroup 1 and 2 corresponded to epitype A and exhibited similar histopathological (low pathological stage and grade) and mutational (frequent FGFR3 and infrequent TP53 mutations) associations.
However, their relatively infrequent mutation and/or association with specific tumor groups could limit their value as biomarkers or therapeutic targets.
Recent cross-sectional population-based studies of community-residing older adults have found significant associations between infrequent contact with family and friends and lower scores on selected components of the SF-12 [ 21] and SF-36 measures of HRQL [ 22].
Holla et al. found no association for frequent use of the pain coping strategy distraction, but found a significant association for infrequent use of the pain coping strategy worrying [ 20].
However, because this disease is so infrequent in humans, positive association with EMCV is difficult to establish.
41 detected a significant association between infrequent summer outdoor activity and the risk of MS in Norway between 16 and 18 years.
Therefore, it is apparent that diseases linked to VE deficiency will only occur in association with infrequent syndromes of impairment of VE intake and its maintenance, such as abetalipoproteinaemia or the familial isolated VE deficiency syndrome.
However, the findings from the Nurses Health Studyy in the United States – only one published prospective data on the association between BM frequency and female colorectal cancer risk (Dukas et al, 2000) – did not support an association between infrequent BMs and the risk of colorectal cancer.
Ocular involvement in patients with IgAN is infrequent, and the most common association is with uveitis [8 11].
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