Some genetic studies have reported infrequent associations of specific genes with TS, including the mutation of SLITRK1 encoding SLIT and NTRK-like protein 1 and a rare functional mutation in the HDC gene encoding L-histidine decarboxylase [ 2- 9].
However, their relatively infrequent mutation and/or association with specific tumor groups could limit their value as biomarkers or therapeutic targets.
In the present investigation, subgroup 1 and 2 corresponded to epitype A and exhibited similar histopathological (low pathological stage and grade) and mutational (frequent FGFR3 and infrequent TP53 mutations) associations.
This interpretation is corroborated by the association observed between infrequent tooth brushing and infrequent dental visits, and infrequent tooth brushing and having never visited a dentist.
However, because this disease is so infrequent in humans, positive association with EMCV is difficult to establish.
41 detected a significant association between infrequent summer outdoor activity and the risk of MS in Norway between 16 and 18 years.
Therefore, it is apparent that diseases linked to VE deficiency will only occur in association with infrequent syndromes of impairment of VE intake and its maintenance, such as abetalipoproteinaemia or the familial isolated VE deficiency syndrome.
Recent cross-sectional population-based studies of community-residing older adults have found significant associations between infrequent contact with family and friends and lower scores on selected components of the SF-12 [ 21] and SF-36 measures of HRQL [ 22].
Ocular involvement in patients with IgAN is infrequent, and the most common association is with uveitis [8 11].
A reconciling model posits that transcription initiates by virtue of infrequent yet stable and productive association of factors at target genes (ChIP).
