The Validation component needs to know the identifier of the message that will be created and also needs to inform the parameters that will fill the "%s" gaps.
When necessary, we shall use superscripts to inform the parameters of attack, namely the type of attack (parallel or sequential) using the respective symbols (∥ or ∴), and the intrusion adversarial effort (IAE) λ.
Published data from eastern Zimbabwe [8], [37] were used to inform the parameters specifying sexual behaviour, but the broad behavioural patterns are similar to reports in other settings [38], [39], [40].
In all cases in this study exact numbers were available, and so these were used to inform the parameters of each Beta distribution directly.
Bayesian theory fits quite well with the need for mechanistic PK/PD models to incorporate prior knowledge to adequately inform the parameters of the system of ordinary differential equations.
For situations in which existing data are available to inform the parameters of the data generating model, one could consider adopting a Bayesian approach and simulating the posterior distribution for a design's power.
Indeed, associations identified based on statistical analyses can be used to inform the parameters used in process-based models, and process-based models can conversely identify field studies that might be useful.
To inform the parameter of RR of developing cancer given treatment modality (i.e. relative risk of developing cancer given patients have undergone excision vs. no excision), we conducted a comprehensive systematic literature search to identify clinical studies that investigated the malignant transformation rate (MTR) given treatment modality (Additional file 1: Table S3).
In effect, we assessed cost-effectiveness at 100 ng ml−1 as this was the cut-off in the key quantitative studies which informed the parameter estimates.
While we did not set out to evaluate FIT at different cut-off values (because of lack of high-quality data at the time the model was parameterized) the key studies which informed the parameter estimates for FIT performance characteristics used a cut-off of 100 ng/mL.
