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The phrase "informs the direction" is correct and usable in written English.
You can use it when you want to express the idea of providing information that influences the course of action or decisions. For example: "The survey results informs the direction of the company's marketing strategy."
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However, mutual information is symmetric and does not inform the direction the information flows.
Prior information collected in the pilot DCE was used to inform the direction and magnitude of the likely coefficients in the final model.
Lazarus's growing interest in the plight of Russian-Jewish exiles fleeing the pogroms informed the direction she took in this commissioned poem.
However, there was no evidence to inform the direction of this association as improvements were substantial in both groups.
Prior to the interviews, the commentaries the raters had written were reviewed and used to inform the direction of the discussion.
Other vehicle interaction systems are in development, and what is learnt in this huge, real world, experiment will help inform the direction they take.
This isn't an aircraft that will go into service, it's a tech demo, but it will prove technologies, demonstrate capabilities and inform the direction we [the UK] are going in".
Ready cues that informed the direction of the impending response triggered preparatory neural activity in the posterior zone of dACC and strengthened functional connectivity with the anterior and caudal zones of dACC, as well as perigenual anterior cingulate cortex, frontal operculum, dorsolateral prefrontal cortex, sensory association cortices, and extra-pyramidal motor areas.
While these findings cannot be interpreted as causal, given the descriptive nature of the paper, they contribute to understanding gender test score gaps, with results useful in informing the direction of future interventions aimed at reducing the gender test score gap.
You can also read the Input Papers that inform the direction and scope of the WDR.
We are speaking to development partners to inform the direction of their investment; to governments to enable them to rethink their strategies as they relate to young people's sexual and reproductive health, and to fellow youth to act together in advocating for more responsive programs and policies on sexual and reproductive health for young people.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com