The adherence topics varied at different time points, according to our ongoing assessments of what information would be most useful to inform trial implementation at the time.
Access to patient data is required to inform trial design and trial feasibility assessment and so information and governance approval would be required for the generic process rather than a specific trial.
Identification of active ingredients in ICP interventions can inform trial design and clinical decision-making.
There are no studies comparing radiation techniques to inform trial design.
These data require validation and may inform trial design and therapy.
Clinical trials can benefit from patient perspectives to inform trial design, such as choice of outcome measures.
Rigorous attention to these issues at project inception can inform trial design and conduct by matching research approaches to the context in which trials are to be conducted.
We make recommendations for the standardisation of reporting for future studies, such as appropriate cohort characterisation and documentation of methodologies to facilitate comparisons and inform trial design.
Incidence data on severe maternal complications, life-threatening conditions, maternal deaths and birth outcomes are essential for clinical audit and to inform trial design of the types and frequency of expected severe adverse events (SAEs).
