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Another attractive aspect of pair analysis for informing lead optimization is that the analysis is directly in the form of a change in chemical structure.
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This question has particular salience, for while it is too late to alter the structure of AR5, a priori identification of potential overlooked areas can be used to inform lead authors, influence the chapter review stage, and guide the strategic recruitment of contributing authors.
The recognition of the power of photography to persuade and inform led to a form of documentary photography known as social documentation, or social photography.
It's in the service of creating vulnerability and intimacy, and informing the lead of where you're coming from.
The case of Ebola virus disease in West Africa demonstrated vividly how, in managing an outbreak, good information is as important as medical therapy, and failure to inform can lead to disaster.
In theory, one of the roles of politicians is to conduct, inform and lead a national debate on the issues of the day.
When your goal is to inform and lead, employing a more directive approach with fewer words is more effective.
Curiosity is the engine that informs, leads, and inspires conversation.
At the outset of the initiative it was expected that rigorous evidence reviews informing decisions would lead to practice changes.
"The question now is how do we ensure that this new information leads to more informed and more dynamic and dramatic action?" Sullivan says.
Avaaz responds to its members as much as it informs and leads them.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com