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The results informed our hypothesis that the broad responsiveness of one or more immune pathways is associated with the potential of the inflammatory process to mediate joint destruction.
Local holders of traditional ecological knowledge, who distinguish between mainland and island wolf forms, also informed our hypothesis that genetic differentiation might occur between wolves from these adjacent environments.
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We use this anecdotal interpretation of the clusters to inform our hypotheses about the mechanisms that affect the formation of co-editing similarities.
While there have been no studies investigating the effect of gender on these variables in Kazakhstan before, previous research carried out elsewhere inform our hypotheses: In South Africa, in comparison with male migrants, women migrants are likely to have fewer sexual partners and report lower levels of condom use [ 20 ].
To strengthen the internal validity of the study, we inform our reasoning about the hypotheses both in visual analysis of the clusters and in previous literature on the subject.
Determining the answer to these strictly defined questions then informs our development of further hypothesis-driven research aims.
Understanding the basal liver gene expression patterns is a necessary first step in addressing this hypothesis and will inform our assessments of adverse drug reactions as the liver plays a central role in drug metabolism and biotransformation.
The model estimates should be taken as evidence to inform (rather than test) our hypothesis, especially given the limited number of confounders and that these were secondary analyses.
However, given that these mechanisms are often not known, the modeling approach constitutes an approximation to the understanding of a complex dynamic system based on available information and informed hypothesis.
The subjects were not informed about the hypothesis of our study (i.e., our expectation that migraine would influence interictal pain thresholds).
Previous literature informed their hypothesis that students from different countries, Japan versus the USA, would perform differentially on the assessment given differential cultural notions of what constitutes desirable social skills, e.g., subtle communication versus direct.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com