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The most informative subjects are selected as those with the smallest mean squared estimation error.
Active learning aims to select the most informative subjects for labeling to decrease the amount of labeling requests.
Therefore, to capture how independent and collectively informative subjects' pairs of responses were, we calculated the improvement in accuracy afforded by averaging the responses together.
AI was present in 2 (10%) of 21 informative subjects.
As already pointed out, the increase in power is due to the selection of the most informative subjects.
All informative subjects with deletions extending beyond Xp22.3 had completely skewed X-inactivation, with the deleted X presumably inactive (Table 2).
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The 79 proteins were further analyzed by one-dimensional cluster analysis across all informative study subjects which were readily distinguished from controls as shown in Additional file 7. The 79 BAL proteins are listed by their UniProt identifiers in Additional file 8.
This includes the specific research design of the project, the use of pharmaceuticals (especially if they have not yet received full F.D.A. approval), a completely informative subject consent process and, when appropriate, the implementation of a more thorough, campus-wide education project required of all researchers and staff involved in any research employing human subjects.
Considering the results in Figure 5, there may be some good reasons to spend more counseling time with non-informative subjects, that is, the individuals belonging to at-risk families where no known mutation is found.
The particularity of non-informative subjects was also confirmed by their lower level of specific knowledge when compared with true-positive individuals (ie mutated): 8.3±1.2 for these latter (P=0.005 and P=0.021 for the comparison of ratio), while their level of non-specific knowledge did not differ (8.8±1.0 versus 8.8±1.2, P=0.49).
The largest and most informative study on this subject to date is the pooled analysis of 11 miners' cohorts published by Darby et al (1995a).
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