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Informative pedigree information of one family is shown, together with the corresponding serotypes as well as the MIB inheritance patterns (Fig. 2).
P1 was the most informative pedigree in terms of mapped markers (274 polymorphic loci).
When combining data on both sexes, 2557 individuals were scored for at least one trait, with the informative pedigree consisting of 2368 maternal links and 1573 paternal links.
Here we applied new high-density genotyping technology to the highly informative pedigree structure of the incipient Collaborative Cross (CC) to investigate the roles of sex and genetic background in mammalian recombination.
For males a total of 1369 individuals were measured for at least one trait and the informative pedigree consisted of 1586 maternal links and 1077 paternal links (of which 141 were dummy sires).
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The results also support the general approach used here of identifying homogeneous subsets and restricting analysis to a limited set of informative pedigrees.
We investigate, however, theoretical results available that could be used to obtain some more simply computed but potentially less informative tests of pedigree relationship.
In addition, even when markers of the same type are co-localized, they are likely to be of value; any given microsatellite is not informative in every pedigree, and closely localized BACs may represent the beginning of an overlapping contig.
Rather than using standard RAD to screen for a highly redundant set of informative SNPs within pedigrees, we employed a variant of this technology; double digest RAD (ddRAD; [ 23]), which allowed a subset of the RAD loci to be surveyed more straightforwardly and more economically.
Since the observations used in this study were collected on four large groups of half-sibs, the second objective of the study was to test whether including SNP information could help reach more precise estimates than using pedigree information only when the pedigree of the population is poorly informative.
For genome and QTL mapping in outbred plants, TGOP is more informative than any other pedigree used so far in the genus Picea [ 14].
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