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SISCOM[82] encodes spectra by selecting the most informative peaks within homologous ion series.
The idea is to keep only a finite number of informative peaks within a specified mass range, say ± x Da, regardless of where the center is.
Such a result demonstrates a strong advantages in phenotype discrimination over the previous work [ 17, 23, 24], just as we pointed out before, which employed quite complicate evolutionary algorithm (PSO-SVM) to collect a set of informative peaks and achieved 90%+ diagnosis accuracy under a 5-fold cross validation [ 23].
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The most informative peak separation can be obtained with saline:acetonitrile mixture (1 1 ÷1:3) containing 0.06-0.08% TFA.
The relatively small number of pronounced or informative expression peaks for this gene pair could influence our statistical test due to many small fluctuations from noise or background expression.
Maximum pollutant exposure did not yield additional evidence of a relation with the excess leukemia risk compared with average levels, and this was particularly true for PM10, suggesting that usual exposure, the one generally monitored by regulatory agencies, is not less informative than peak exposures in influencing disease risk.
The signals in the near-red region are more informative; the peak at 644 646 nm is diagnostic of the binding of CO to cytochrome d exclusively, whilst the minimum at 626 632 is due to loss of absorbance of the Fe(II) form of haem d (Fig. 5A C).
In a rugged fitness landscape, there is additionally no guarantee that the height of or distance to the greedy peak are informative about the height of or distance to these peaks.
Tandem SNP sequences were considered informative when two peaks were observed in DNA extracted from maternal buccal swabs or maternal white blood cells, and three peaks were observed in DNA from maternal plasma, by CTCE analysis ( Figure 3).
The median value of peak information among informative neurons was 0.22 bits, with an interquartile range of 0.12 0.42 bits.
The median value of peak information among informative signals was 0.18 bits, with an interquartile range of 0.12 0.31 bits.
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