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The number of transmembrane domains a protein has can be informative of function.
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Thus, the informative loss-of-function alleles of vital genes are absent from a modifier screen that emerges from an inbred line.
Gibson et al. [ 24], utilised exome-chip data to demonstrate patterns of linkage disequilibrium and subsequent haplotype structure to be informative of gene function and possible relationships between genes and specific phenotype clusters.
However, this specific class of "chemical suppression" is not likely informative of gene functions per se because the drug is often not well characterized and usually restores the function of a mutant protein structurally through direct binding.
We found that the distribution of node connectivity varied by functional category and could be informative for function prediction.
The former tends to be much more informative in terms of function prediction: Authors' response: Historically, most domain libraries (e.g. SMART and Pfam) started with the collection of models that describe enzymatic/biochemical function and hence characterized by folds (as evident in the early versions of domain libraries).
Thus, the classification of sirtuins based on sequence homology is informative of their biochemical functions, especially acyl group specificity.
Thus the autocorrelation between pixels in different lines is rather small, and the informative part of autocorrelation function is mainly reduced to autocorrelation between pixels in the same line of the image.
Furthermore, the systematic downregulation of Msi1/Msi2 and high frequency of Msi1 mutations in kidney tumors suggests that kidney would be an informative model for studying Msi loss-of-function and its consequences in cancer.
This type of distinct but major peak may be informative for prediction of functions of multidomain, multifunctional proteins.
The use of loss-of-function mutations is an informative approach to identify the functions of a given gene.
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