MVPA can be considered as a multi-objective pattern classification problem with the aim to optimize response patterns, in which informative voxels interacting with each other are selected, achieving high classification accuracy associated with cognitive stimulus conditions.
Is information always informative?
Unfortunately, neither of these approaches are immediately informative regarding the identity of the interacting TCRs.
HyperModules is a biological network-mining algorithm that reveals modules of interacting genes with clinically informative disease mutations.
However, in a conservation context identifying appropriate spatial boundaries at which these processes interact can be highly informative, even if the underlying processes themselves are not yet evident [16].
Since genetic interactions are an informative means to discover functional relationships among genes [18], we used a recently developed eSGA (E. coli Synthetic Genetic Array) approach [19] to identify E. coli genes that genetically interact with rbbA and yhjD.
In this context, it would be informative to also examine whether RIF1, a 53BP1 interacting partner (Chapman et al, 2013; Escribano-Díaz et al, 2013; Feng et al, 2013), has the same effect at uncapped telomeres.
Thus, it is informative that a mutation in Vac14p that interrupts its ability to interact with Atg18p also results in PI 3,5 P2 levels that are consistent with a partial release of Atg18p inhibition of Fab1p.
Even though functional studies in DCs might be informative, it is important to take into account that the main cells to interact with HZ in the host are monocytes in circulation as well as tissue Mφ [7], [9], [12].
Looking a little further down the list we learn other transcript features that are highly informative of driver events, such as having breakpoints in the CDS and conserving domains shared with or interacting with known oncogenes.
