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Significant genes are associated to both the most informative functional terms, avoiding redundancy of information, and the most representative temporal patterns, thus improving the readability of the results.
With numerous predicted mammalian protein-coding loci still having no informative functional annotation and even less insight into the function of the many non-protein-coding genes, detailed knowledge of a transcript's expression pattern can provide a valuable window on its function.
Furthermore, the region contains 192 gene models, 48 of which have informative functional annotations (Supplementary Table 13).
Beyond the informative functional relations we employed the ability of NEA to evaluate internal consistency of a given set.
Interestingly, transposase-related genes accounted for ~25% of all strain-specific genes with an informative functional annotation.
Our aim was to aid 'classical' morphometric treatments, where taxonomists have established decisive and informative functional traits.
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We employed the FunCoup resource [32], a set of programs and a custom collection of datasets informative regarding functional coupling (interactions), to generate a zebrafish interactome.
Over-expression studies have been informative in functional analysis of KNOX1[ 26- 28].
We next tested the extent to which the co-evolutionary network overlaps other system-biology related networks that had been reported to be informative of functional association between proteins (see Section 2 for details regarding networks reconstruction).
Our approach shows that evolutionary conservation is a powerful filter to make protein interaction data informative about functional similarities between the interacting proteins, and it establishes graph alignment as a powerful tool for the comparative analysis of data from highly diverged species.
Use of multiple, informative, putative functional markers; testing for and correcting population substructure; and use of biologically relevant, quantitative phenotypes (endophenotypes) in addition to the disease phenotype are additional approaches to address heterogeneity and potentially to increase power in association studies.
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