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Another informative baseline might be a conservation system designed by expert-opinion rather than data sets in conservation planning software [61].
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While we only used 18 informative locations, our baseline lateral tibiofemoral CDI had a better correlation with lateral JSW (r = 0.81, p < 0.0001).
We believe that the placement of informative locations on baseline and follow-up images was accurate because we used a robust coordinate system, trained the reader to detect errors, found good construct validity, and detected large measures of responsiveness.
To co-locate the corresponding informative locations on baseline and follow-up images, we used dual screens to permit simultaneous visual comparison of the MR image sets.In the first step the reader indicated the most medial and lateral MR image slices within the knee.
Missing data on MMSE at baseline was informative; here it was associated with higher delirium risk.
Is information always informative?
In our opinion defining a responder as a patient with ≥50% reduction of headache frequency from baseline is more informative, although other definitions, e.g., ≥25% reduction of headache frequency from baseline, can be clinically meaningful for MOH patients [10].
Indeed, women enrolled in the Australian Ovarian Cancer Study demonstrated sharp declines in QOL preceding drop out and those who dropped out early had poorer QOL at baseline, suggesting an informative missing PRO data pattern [29].
Further effort to determine at what cognitive level they returned to baseline would be informative.
Comorbidities are likely less informative in determining variances in baseline costs if looking at clinical trial populations in isolation.
One method uses a biological reference (R-score), which is particularly useful if there is a well-defined or biologically meaningful reference sample that can be used as a baseline to make informative comparisons across different experiments.
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