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The Cochrane handbook suggests that authors of Cochrane reviews may optionally add up to three extra fields to the characteristics of included studies table, including one to report information on trial funding.
Information on trial design was available for only one postapproval study: the postapproval study of besifloxacin was required to be randomised and vehicle-controlled, and to enrol at least 300 patients.
The 46 Cochrane reviews that provided partial or full information on trial funding sources did so in between one and seven locations within each review, with more than 20 different patterns observed for reporting this information.
Information on trial funding and trial author-industry ties was reported in one to seven locations within each review, with no consistent reporting location observed.
Two more recent studies from one double-blind controlled intervention trial in mild AD reported considerable information on trial design and procedures, which facilitates appreciation of the results [ 29, 30].
Of the 42 Cochrane reviews that had at least one review author with disclosed financial ties to industry, 12 (29%) reported information on trial funding sources compared with 34 of 109 reviews (31%) in which no review authors disclosed financial ties to industry.
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Getting information on trials is best done by consulting medical professionals and "consumer" advocacy Web sites.
Publication bias in human clinical trials has been measured by comparing publications to meeting abstracts, information on trials approved by human subjects ethics review committees, trial registries, and trials submitted to drug regulatory authorities [ 6- 12].
Our user analysis showed that most patients appreciated being able to search for suitable trials themselves, and that patients relied on the Internet, and not their doctor, for information on trials.
The ICTRP also provides a search portal that collects and indexes some basic information on trials from most of the primary registries and attempts to group trials that are registered in more than one registry in the search results.
The registration number of this trial is UMIN000001026, and information on the trial can be found online at [ 12].
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