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Information on the compounds reported here will be useful in the development of new lead compounds as potential therapeutic agents for the treatment of Chagas disease and as biological probes to study the role that cruzain plays in the pathology.
A comprehensive in-depth overview of effect-directed analysis (EDA)—the approach of choice to provide information on the compounds causing the observed effects—has been published by the respective NORMAN Working Group to meet the increasing demands for its most efficient application [11].
In order to obtain more information on the compounds detected by MALDI-MS directissueue profiling and to confirm that these peaks correspond to saponins, tandem mass spectrometry (MS/MS) was undertaken directly on tissue section.
For example, Tohsato et al. [ 9] align pathways based on enzyme EC number similarity only, discarding information on the compounds involved.
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The image is then displayed in the portlet, and becomes a link to the ChemSpider web page where additional information on the compound can be found.
However, in vivo studies are often compromised by a lack of sufficient information on the compound pharmacokinetics necessary to ensure target engagement and also by the context-free analysis of ubiquitous cellular signaling pathways downstream from the target.
All the information on the compound names of the medicinal materials can be downloaded as an ontology file, written in the Web Ontology Language (OWL) using the RDF/XML syntax, from the "Download" menu on our site.
Further information on the compound may be obtained by double-clicking a table row containing an identifier in the databases tab of the compound's information dialog, as in Figure 6.
After information on the compound names of medicinal materials was extracted from about 4000 journal articles in MEDLINE and PMC, about 14,000 chemical compounds from 536 medicinal materials were identified.
Hence, it is of great value to account for all publicly available information on the compound-centric aspects in a given drug discovery project in order to make the most educated decision, specifically on the 'tractability' of a given chemotype.
The aim of this study was to construct a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine (TM-MC), for which medicinal materials are listed in the three Northeast Asia national pharmacopoeias, and for which information on the compound names of medicinal materials can easily be confirmed in PubMed online.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com